How Vitamin D affects AMD
A study published in Marturitas found that Vitamin D may help prevent age-related macular degeneration (AMD).
According to the authors, Vitamin D may be involved in ocular function in older adults, but there is no current consensus on a possible association between circulating concentrations of 25-hydroxyvitamin D (25OHD) and the occurrence of AMD.
Researchers conducted a Medline search in November 2015, with no date limit, using the terms:
â¢ Vitamin D
â¢ Vitamin D deficiency
â¢ Cholecalciferol combined with age-related macular degeneration
â¢ Macular degeneration
â¢ Retinal degeneration
â¢ Macula lutea
Researchers say fixed and random-effects meta-analyses were performed to compute standard mean difference in 25OHD concentration between AMD and non-AMD patients and to identify the AMD risk according to circulating 25OHD concentration. Of the 243 retrieved studies, 11 observational studiesâ10 cross-sectional studies and one cohort studyâmet the selection criteria.
The study found that circulating 25OHD concentration was 15 percent lower in AMD compared with non-AMD on average. AMD was inversely associated with the highest 25OHD quintile compared with the, notably late AMD.
Researchers concluded that high 25OHD concentrations may be protective against AMD.