Disquafosol improves dryness symptoms for contact lens wearers
A study evaluating the efficacy of topical application of 3% diquafosol tetrasodium solution for the treatment of soft contact lens wearers with dryness found the solution improved biomarker of membrane-associated mucins, tear film break-up time (TBUT), staining of cornea and conjunctiva, and subjective symptoms.
In addition to clinical tests and subjective symptoms, researchers assessed the fluorescence intensity of wheat germ agglutinin conjugate of fluorescein (F-WGA) used as a marker of membrane-associated mucins and sialic acid concentration in tear fluids as a marker of secreted mucins.
Researchers treated for four weeks 12 soft contact lens wearers with dryness symptoms with diquafosol. Clinical tests included TBUT, corneal and conjunctival fluorescein staining scores, and Schirmer values. Researchers evaluated subjective symptoms using the Dry Eye-Related Quality-of-Life Score (DEQS).
Fluorescence intensities in the central cornea were measured by fluorophotometry at five minutes after a 5% F-WGA solution was applied to the eye. The tears collected by the Schirmer test strips were analyzed by high-performance liquid chromatography, and the concentrations of sialic acid, total protein, and the four major tear proteins secretory IgA, lactoferrin, lipocalin-1, and lysozyme proteins were measured.
The study found that comparing the results before and after diquafosol treatment, TBUT, kerato-conjunctival staining score, corneal staining score, and DEQS score showed statistically significant improvements. The study also found that F-WGA fluorescence intensities significantly increased after treatment, whereas the concentrations of sialic acid and tear proteins remained unchanged.