How much the lamina cribrosa curves inward could become a useful prognostic factor in glaucoma.
A recent study in early-stage patients with primary open-angle glaucoma (POAG) found a direct relationship between the degree of deformation in the lamina cribrosa and progressive loss of visual field, said Ahnul Ha, MD.
"The lamina cribrosa is already known as the primary site of pathogenesis in glaucoma," said Dr. Ha, Department of Ophthalmology, Seoul National University Hospital, Seoul, South Korea.
Lamina cribrosa deformation can directly block the excimer cells and the disturbed blood supply can accelerate retinal ganglion cell injury, Dr. Ha said.
"We found that with greater lamina cribrosa deformation, RGC axons are increasing vulnerable to further glaucomatous injury," Dr. Ha added. "Baseline lamina cribrosa morphology may eventually serve as a prognostic factor in patients with primary open-angle glaucoma."
The study followed 101 eyes with early-stage POAG for a mean of 3.6 years. In addition to conventional measures of glaucoma such as IOP and visual field parameters, researchers measured the deformation of the lamina cribrosa and created a lamina cribrosa curvature index (LCCI) as a measure of lamina cribrosa morphological change.
Ahnul Ha, MD
e. [email protected]
This article was adapted from Dr. Ha's presentation at the 2017 meeting of the American Academy of Ophthalmology. Dr. Ha did not indicate a proprietary interest in the subject matter.