Univariate analysis showed four factors associated with visual field progression, greater IOP fluctuation, greater initial visual field PSD, mean baseline LCD, and mean baseline LCCI.
"In the multivariate analysis, only the mean baseline LCCI was statistically significant," Dr. Ha said. "A baseline LCI of 152.4 micrometers was identified as the significant break point. If the baseline LCCI is greater than 152.4 micrometers, the visual field progressed by -0.01 dB per year as the LCCI increased by one unit. Greater lamina cribrosa curvature places a heavier burden on the RGC axons."
Increasing posterior lamina cribrosa bowing induced by elevated IOP creates increasing stress and strain on axons, blood vessels, and other tissues. The mechanical response of the lamina cribrosa under stress from elevated IOP is affected by age, racial differences, and variation between individuals.
Participants ranged from the late 40s to the mid-70s in age. And as expected, the rate of MD progression in the study group was affected by age at baseline.
Ahnul Ha, MD
e. [email protected]
This article was adapted from Dr. Ha's presentation at the 2017 meeting of the American Academy of Ophthalmology. Dr. Ha did not indicate a proprietary interest in the subject matter.