This case study involves a diagnosis of arteriovenous (AV) malformations of the iris. Evaluation warranted dilation of the pupil, thorough retinal examination, and visualization of the posterior side of the iris. Because the abnormal iris vasculature may not be the primary site of the abnormality in question, careful examination of the conjunctival vasculature is also needed.
Vascular abnormalities of the iris and ciliary body can take on an impressive appearance, or they can be very subtle and easily missed. In addition, they can present a diagnostic quandary if they are difficult to visualize or extend or arise from the posterior segment side of the iris.
A patient presented recently with a vascular abnormality which caused me to pause and investigate further in order to sort out a diagnosis, prognosis, and the need (or lack thereof) for a referral for more specialized care.
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A 59-year-old Caucasian female was referred for a comprehensive eye examination as per a recent diagnosis of type 2 diabetes mellitus. She had no complaints and wore reading glasses as needed. Medical history was remarkable for systemic hypertension, type 2 diabetes mellitus, and high cholesterol. Her medications included hydrochlorothiazide and a generic statin.
She was newly diagnosed with diabetes; she was not yet prescribed anything for glucose control and was working on dietary changes. Family history was remarkable for diabetes, systemic hypertension, and cataracts. She also had an uncle who was blind in one eye, but she did not know why.
Entering unaided distance visual acuities were 20/25 in the right eye and 20/20-2 in the left eye. Pupil function was normal in each eye, and extraocular muscle function was unremarkable for each eye. Confrontation visual field assessment showed frankly full visual fields for each eye, and intraocular pressure (IOP) assessment by means of rebound tonometry was 17 mm Hg in the right eye and 19 mm Hg in the left eye. The patient was found to have a low amount of astigmatism in each eye with best-corrected visual acuities of 20/20 in each eye.
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Anterior segment examination of the right eye showed unremarkable lids and lashes, open anterior chamber angles, a clear cornea, quiet conjunctivae, and a quiet anterior chamber with an iris of normal architecture. Examination of the left anterior chamber was essentially the same except for a prominent vascular abnormality of the iris at the inferior temporal aspect of the limbus (Figure 1).
The examination of this abnormality under high magnification via slit lamp yielded no additional information. I also viewed the patient’s anterior chamber angles by means of gonioscopy, and no other abnormalities were noted. The abnormal blood vessel did not appear to extend further into the angle when viewed in this fashion. There were no signs of vascular compromise, such as hemorrhaging.
1. Shields JA, Streicher TF, Spirkova JH, Stubna M, Shields CL. Arteriovenous malformation of the iris in 14 cases. Arch Ophthalmol. 2006 Mar;124(3):370-5.